hrp0086p1-p699 | Endocrinology and Multisystemic Diseases P1 | ESPE2016

Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity

Seiltgens Cristian , Cristi Francisca , Iruretagoyena Mirentxu , Perez-Mateluna Guillermo , Talesnik Eduardo , Hogdson Isabel , Martinez-Aguayo Alejandro , Borzutzky Arturo

Background: Children with more than one AID (pediatric polyautoimmunity) may have a stronger genetic component than children with a single AID. PTPN22 C1858T SNP has been associated with multiple different AIDs in adults and children.Objective and hypotheses: Evaluate the association of PTPN22 C1858T gene polymorphism with pediatric polyautoimmunity.Method: A cross-sectional study was performed in subjects with an AID of p...

hrp0086p1-p698 | Endocrinology and Multisystemic Diseases P1 | ESPE2016

Clusters of Autoinmune Diseases in Children

Seiltgens Cristian , Iruretagoyena Mirentxu , Melendez Patricia , Ponce Maria Jesus , Talesnik Eduardo , Mendez Cecilia , Godoy Claudia , Martinez-Aguayo Alejandro , Hogdson Isabel , Harris Paul , Gana Juan Carlos , Riera Francisca , Garcia Hernan , Cattani Andreina , Borzutzky Arturo

Background: Autoimmune diseases (AIDs) have familial aggregation and frequently share a common genetic background, but few studies have evaluated autoimmune clusters in children with AIDs and their families.Objective and hypotheses: To identify clusters of AIDs in children and their first-degree relatives.Method: A cross-sectional study was performed in subjects with an AID of pediatric onset (<18 years) recruited at Pediatric ...